Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03303-1
Abstract: Ebola virus (EBOV) causes severe human disease with a high case fatality rate. The balance of evidence implies that the virus circulates in bats. The molecular basis for host–viral interactions, including the role for phosphorylation… read more here.
Keywords: phosphorylation; vp35 phosphorylation; role; ebola ... See more keywords
Molecular dynamics exploration of the binding mechanism and properties of single-walled carbon nanotube to WT and mutant VP35 FBP region of Ebola virus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Physics"
DOI: 10.1007/s10867-016-9440-5
Abstract: VP35 of Ebola viruses (EBOVs) is an attractive potential target because of its multifunction. All-atom molecular dynamics (MD) simulations and Molecular Mechanics Generalized Born surface area (MM/GBSA) energy calculations are performed to investigate the single-walled… read more here.
Keywords: molecular dynamics; walled carbon; carbon nanotube; single walled ... See more keywords
Modeling the 2014-2015 Ebola Virus Disease Outbreaks in Sierra Leone, Guinea, and Liberia with Effect of High- and Low-risk Susceptible Individuals.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of mathematical biology"
DOI: 10.1007/s11538-020-00779-y
Abstract: Ebola virus disease (EVD) is a rare but fatal disease of humans and other primates caused by Ebola viruses. Study shows that the 2014-2015 EVD outbreak causes more than 10,000 deaths. In this paper, we… read more here.
Keywords: leone guinea; disease; sierra leone; ebola ... See more keywords
Assessing the effects of modeling the spectrum of clinical symptoms on the dynamics and control of Ebola.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.01.013
Abstract: Mathematical modelers have attempted to capture the dynamics of Ebola transmission and to evaluate the effectiveness of control measures, as well as to make predictions about ongoing outbreaks. Many of their models consider only infections… read more here.
Keywords: reproduction number; clinical symptoms; spectrum clinical; basic reproduction ... See more keywords
Tackling the COVID-19 pandemic in West Africa: Have we learned from Ebola in Guinea?
Sign Up to like & getrecommendations! Published in 2020 at "Preventive Medicine Reports"
DOI: 10.1016/j.pmedr.2020.101206
Abstract: The COVID-19 pandemic is rapidly spreading in Guinea. Of the three West African countries that experienced the Ebola epidemic in 2014–2016, Guinea is currently the most affected country, with 4841 confirmed cases, compared to 542… read more here.
Keywords: guinea; response; sierra leone; ebola ... See more keywords
Interest in an Ebola vaccine among a U.S. national sample during the height of the 2014-2016 Ebola outbreak in West Africa.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.11.093
Abstract: To better understand the association between Ebola-related attitudes and interest in receiving an Ebola virus vaccine, a survey was administered to a U.S. national sample using GfK's KnowledgePanel®. Among participants (N=1417), 34.1% expressed interest in… read more here.
Keywords: national sample; ebola vaccine; ebola; interest ... See more keywords
Adjuvant selection impacts the correlates of vaccine protection against Ebola infection.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.05.009
Abstract: The establishment of correlates of protection is particularly relevant in the context of rare, highly lethal pathogens such as filoviruses. We previously demonstrated that an Ebola glycoprotein virus-like particle (VLP) vaccine, when given as two… read more here.
Keywords: adjuvant selection; protection; protection ebola; ebola ... See more keywords
Ebola Outbreak in Democratic Republic of Congo: Lessons Learned, or Ignored?
Sign Up to like & getrecommendations! Published in 2020 at "Disaster medicine and public health preparedness"
DOI: 10.1017/dmp.2020.171
Abstract: Infectious diseases became an increasing public health threat as humans transitioned from nomadic hunter-gatherer societies to stable, agrarian communities. It is accurate to say the international community was not optimally prepared for the 2014-2015 Ebola… read more here.
Keywords: democratic republic; medicine; republic congo; ebola ... See more keywords
Introduction of Ebola virus into a remote border district of Sierra Leone, 2014: use of field epidemiology and RNA sequencing to describe chains of transmission
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology and Infection"
DOI: 10.1017/s0950268819000104
Abstract: Abstract In early October 2014, 7 months after the 2014–2015 Ebola epidemic in West Africa began, a cluster of reported deaths in Koinadugu, a remote district of Sierra Leone, was the first evidence of Ebola… read more here.
Keywords: ebola; sierra leone; transmission; district sierra ... See more keywords
Large-scale mapping of the Ebola NP and GP proteins reveals multiple immunoprevalent and conserved CD4 T-cell epitopes
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-0455-2
Abstract: Humankind faces regular outbreaks from emerging viruses, such as Ebola and the current SARS-CoV-2, or from viruses circulating at low levels in the wild animal reservoir. Owing to the suddenness of virus expansion, the lack… read more here.
Keywords: cell epitopes; ebola virus; cell lines; ebola ... See more keywords
Impacts of environmental and socio-economic factors on emergence and epidemic potential of Ebola in Africa
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DOI: 10.1038/s41467-019-12499-6
Abstract: Recent outbreaks of animal-borne emerging infectious diseases have likely been precipitated by a complex interplay of changing ecological, epidemiological and socio-economic factors. Here, we develop modelling methods that capture elements of each of these factors,… read more here.
Keywords: risk; economic factors; impacts environmental; ebola ... See more keywords