ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102032
Abstract: ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription… read more here.
Keywords: alzheimer disease; pathogenesis; apoe4; ebp secretase ... See more keywords