Target discovery of ebselen with a biotinylated probe.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04258f
Abstract: Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which… read more here.
Keywords: discovery ebselen; probe; target discovery; ebselen ... See more keywords
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00448-21
Abstract: We show that ebselen kills pathogenic C. difficile by disrupting its redox homeostasis, changing the normal concentrations of NAD+ and NADH, which are critical for various metabolic functions in cells. However, this antimicrobial action is… read more here.
Keywords: redox associated; biology; clostridioides difficile; ebselen ... See more keywords
In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues
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DOI: 10.3390/ph13030047
Abstract: Scientific research has been underway for decades in order to develop an effective anticancer drug, and it has become crucial to find a novel and effective chemotherapeutics in the case of prostate cancer treatment. Ebselen… read more here.
Keywords: prostate cancer; vitro anti; ebselen; cancer ... See more keywords
The Potential Use of Ebselen in Treatment-Resistant Depression
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DOI: 10.3390/ph15040485
Abstract: Ebselen is an organoselenium compound developed as an antioxidant and subsequently shown to be a glutathione peroxidase (GPx) mimetic. Ebselen shows some efficacy in post-stroke neuroprotection and is currently in trial for the treatment and… read more here.
Keywords: treatment; potential use; treatment resistant; ebselen ... See more keywords
Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.66314
Abstract: Ebselen, a multifunctional organoselenium compound, has been recognized as a potential treatment for diabetes-related disorders. However, the underlying mechanisms whereby ebselen regulates metabolic pathways remain elusive. We discovered that ebselen inhibits lipid phosphatase SHIP2 (Src… read more here.
Keywords: ebselen; diabetic mice; ship2; insulin sensitivity ... See more keywords