Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2-positive cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13419
Abstract: Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2-targeted therapies improved progression-free and overall… read more here.
Keywords: ebselen oxide; oxide derivatives; her2; new allosteric ... See more keywords
Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model
Sign Up to like & getrecommendations! Published in 2018 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2018.1488858
Abstract: Abstract Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti-bacterial, anti-fungal,… read more here.
Keywords: vesicant model; hn2; ebselen oxide; ear vesicant ... See more keywords