Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase
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DOI: 10.1016/j.jorganchem.2021.121822
Abstract: ABSTRACT Ferrocenyl and ruthenocenyl derivatives of ebselen are found to be competitive inhibitors of mammalian TrxR, with IC50 of 4.2 ± 0.3 and 2.5 ± 0.3 µM, respectively. The inhibition of TrxR is selective over… read more here.
Keywords: competitive inhibitors; derivatives ebselen; ebselen selective; inhibitors thioredoxin ... See more keywords