Ruxolitinib treatment for SR-aGVHD in patients with EBV-HLH undergoing allo-HSCT
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03864-y
Abstract: Ruxolitinib is a promising option for treating steroid-refractory acute graft-versus-host disease (SR-aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, we describe ruxolitinib treatment for SR-aGVHD in HSCT patients with Epstein-Barr virus-associated hemophagocytic… read more here.
Keywords: agvhd; ruxolitinib; patients ebv; treatment ... See more keywords
Rituximab-containing immuno-chemotherapy regimens are effective for the elimination of EBV for EBV-HLH with only and mainly B lymphocytes of EBV infection.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107606
Abstract: Patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) have a poor prognosis. This study investigated the efficacy of rituximab-containing immuno-chemotherapy regimens for EBV-HLH. In this study, 15 patients were treated with rituximab-containing regimens. The treatment efficacy… read more here.
Keywords: ebv hlh; containing immuno; immuno chemotherapy; rituximab containing ... See more keywords
Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomics
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62090-5
Abstract: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a fatal hyperinflammatory disorder distinct from self-limiting EBV-induced infectious mononucleosis (IM). However, the immunological mechanisms underlying the divergence between benign EBV infection and fulminant HLH—particularly in the absence of… read more here.
Keywords: ebv hlh; epstein barr; barr virus; single cell ... See more keywords
Specific cytokine patterns in Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis compared to Kawasaki disease in children.
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric hematology and oncology"
DOI: 10.1080/08880018.2023.2186555
Abstract: The aim of the study was to test whether the cytokine profile could be used as a marker to differentiate between Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and Kawasaki disease (KD). A total of 70 hospitalized… read more here.
Keywords: ifn ratio; ebv hlh;
Analysis of clinical characteristics and prognostic factors associated with EBV-associated HLH in children
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2109328
Abstract: ABSTRACT Purpose Our aim is to analyze the clinical characteristics and prognostic factors of Epstein-Barr (EB) virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in children. Methods Children with newly diagnosed HLH were retrospectively analyzed. Results Finally, a total… read more here.
Keywords: hlh; ebv hlh; analysis; elevated degree ... See more keywords
Early Use of Blood Purification in Severe Epstein-Barr Virus–Associated Hemophagocytic Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Pediatrics"
DOI: 10.1542/peds.2019-3197
Abstract: Early incorporation of PE and CRRT with HLH-2004 chemoimmunotherapy may be an effective solution for both short- and long-term control of patients with severe EBV-HLH. Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common type of… read more here.
Keywords: epstein barr; crrt; barr virus; ebv hlh ... See more keywords
Case report: emapalumab treatment for a pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient with cytokine storm enabling allogeneic hematopoietic cell transplantation
Sign Up to like & getrecommendations! Published in 2024 at "Translational Pediatrics"
DOI: 10.21037/tp-24-72
Abstract: Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive immune activation and inflammatory response. Conventional immunotherapy and molecular targeted drugs demonstrate varying efficacy. Cytokine storm, the primary pathogenic mechanism of HLH, is driven… read more here.
Keywords: ebv hlh; treatment; cytokine; case ... See more keywords
Development of a screening score for Hemophagocytic Lymphohistiocytosis among pediatric patients with acute infection of Epstein-Barr virus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.981251
Abstract: Background and aims Deciding when to suspect hemophagocytic lymphohistiocytosis (HLH) and perform diagnostic tests in patients with acute infection of Epstein-Barr virus (EBV) is challenging, given the high prevalence of EBV infection, the life-threatening risk… read more here.
Keywords: pediatric patients; acute infection; ebv; ebv hlh ... See more keywords
Plasma Exosomal Proteomic Pattern of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.821311
Abstract: Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which is caused by EBV infection that is usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis and… read more here.
Keywords: ebv hlh; barr virus; epstein barr; plasma exosomal ... See more keywords