APX-115A, a pan-NADPH Oxidase Inhibitor, Induces Caspase-dependent Cell Death by Suppressing NOX4-ROS Signaling in EBV-infected Retinal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Current Eye Research"
DOI: 10.1080/02713683.2020.1718164
Abstract: ABSTRACT Purpose Epstein-Barr virus is a γ-herpes virus that infects primary B cells and can transform infected cells into immortalized lymphoblastoid cell lines (LCL). The role of EBV in malignancies such as Burkitt’s lymphoma and… read more here.
Keywords: ebv; ebv infected; apx 115a; cell death ... See more keywords
Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B Cells In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01618-18
Abstract: EBV causes tumors in multiple organs, particularly in the oro- and nasopharyngeal area but also in the digestive system. This virus enters the body in the oropharynx and establishes a chronic infection in this area.… read more here.
Keywords: infection; ebv infected; integrin; induces expression ... See more keywords
Galectin-9 Facilitates Epstein-Barr Virus Latent Infection and Lymphomagenesis in Human B Cells
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04932-22
Abstract: The cross talk between Epstein-Barr virus (EBV) and the host cell transcriptome assumes important roles in the oncogenesis of EBV-associated malignancies. Here, we first observed that endogenous Gal-9 expression was persistently increased along with an… read more here.
Keywords: gal expression; cell; infection; ebv ... See more keywords
Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis
Sign Up to like & getrecommendations! Published in 2019 at "BMC Gastroenterology"
DOI: 10.1186/s12876-019-1021-1
Abstract: BackgroundStudies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with various levels of immune dysfunction. In the current… read more here.
Keywords: infection; cirrhosis; liver cirrhosis; ebv infected ... See more keywords
Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells
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DOI: 10.1371/journal.ppat.1010453
Abstract: Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have different phenotypes in B cells. T1 EBV… read more here.
Keywords: irf4; infected cells; ebv infected; expression ... See more keywords
A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.830993
Abstract: Background That Epstein–Barr virus (EBV) infection is associated with systemic lupus erythematosus (SLE) is established. The challenge is to explain mechanistic roles EBV has in SLE pathogenesis. Previous studies identify four examples of autoantibody cross-reactions… read more here.
Keywords: ebv infection; ebv infected; anti ebna1; sle ... See more keywords
Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174118
Abstract: Simple Summary The Epstein–Barr virus (EBV) is a γ-herpes virus that primarily infects human B cells, and more than 90% of adults have experienced infection. EBV+ B cells express several viral proteins, transmitting signals important… read more here.
Keywords: cd4 cells; cd4; infected cells; ebv infected ... See more keywords