Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.06.004
Abstract: CONTEXT A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE… read more here.
Keywords: ec50; bone mineral; phpt; mineral density ... See more keywords
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00054
Abstract: Based on the detailed analysis of the binding mode of diarylpyrimidines (DAPYs) with HIV-1 RT, we designed several subseries of novel NNRTIs, with the aim to probe biologically relevant chemical space of solvent-exposed tolerant regions… read more here.
Keywords: ec50; binding pocket; exposed tolerant; hiv ... See more keywords
Decreased Sensitivity of Leptosphaeria maculans to Pyraclostrobin in Alberta, Canada.
Sign Up to like & getrecommendations! Published in 2020 at "Plant disease"
DOI: 10.1094/pdis-11-19-2461-re
Abstract: Leptosphaeria maculans, the causal agent of blackleg of canola (Brassica napus), can be managed with pyraclostrobin and other strobilurin fungicides. Their frequent application, however, poses a risk for the development of insensitivity in fungal populations.… read more here.
Keywords: ec50; liter; sensitivity; alberta canada ... See more keywords
Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15040445
Abstract: Over the past two years, several variants of SARS-CoV-2 have emerged and spread all over the world. However, infectivity, clinical severity, re-infection, virulence, transmissibility, vaccine responses and escape, and epidemiological aspects have differed between SARS-CoV-2… read more here.
Keywords: ec50; strains belonging; ivermectin; activity ... See more keywords