Development of Escherichia coli Asparaginase II for Immunosensing: A Trade-Off between Receptor Density and Sensing Efficiency
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DOI: 10.1021/acsomega.7b00110
Abstract: The clinical success of Escherichia colil-asparaginase II (EcAII) as a front line chemotherapeutic agent for acute lymphoblastic leukemia (ALL) is often compromised because of its silent inactivation by neutralizing antibodies. Timely detection of silent immune… read more here.
Keywords: escherichia; immobilization; density; sensing efficiency ... See more keywords
Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes
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DOI: 10.3390/molecules29102272
Abstract: L-asparaginases are used in the treatment of acute lymphoblastic leukemia. The aim of this work was to compare the antiproliferative potential and proapoptotic properties of novel L-asparaginases from different structural classes, viz. EcAIII and KpAIII… read more here.
Keywords: crucial therapeutic; ecaii; cell; affinity crucial ... See more keywords