Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04398-6
Abstract: Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand-coordinated events termed kataegis3,7–9. Here… read more here.
Keywords: cancer; base substitutions; clustered mutations; mutational processes ... See more keywords
CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.118
Abstract: Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain present in most RTKs… read more here.
Keywords: pdgfra; ecdna; growth factor; activation ... See more keywords
Abstract 3130: Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3130
Abstract: Oncogene amplification on extrachromosomal DNA (ecDNA) drives rapid tumor evolution, treatment resistance, and poor outcomes for patients. Computational tools can detect ecDNA in whole-genome sequencing (WGS) data from biopsies. However, the lack of longitudinal studies… read more here.
Keywords: barrett esophagus; cancer; ecdna; extrachromosomal dna ... See more keywords
Pioneering insights of extrachromosomal DNA (ecDNA) generation, action and its implications for cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.73479
Abstract: Extrachromosomal DNA (ecDNA) is a cancer-specific circular DNA molecule that is derived from chromosomes. In contrast with linear chromosomes, ecDNA exhibits a unique structure that can be representative of high chromosome accessibility, contributing to hyperactivated… read more here.
Keywords: dna; ecdna; dna ecdna; pioneering insights ... See more keywords