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   Articles with "ecdna" as a keyword



Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57447-9

Abstract: Extrachromosomal circular DNA (ecDNA) has been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC). However, the molecular mechanisms of… read more here.

Keywords: hpv; hybrid ecdna; ecdna; tumor ... See more keywords

Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA

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recommendations! Published in 2022 at "Nature"

DOI: 10.1038/s41586-022-04398-6

Abstract: Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand-coordinated events termed kataegis3,7–9. Here… read more here.

Keywords: cancer; base substitutions; clustered mutations; mutational processes ... See more keywords

CSIG-06. PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA AS AN ONCOGENIC DRIVER IN GLIOBLASTOMA

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recommendations! Published in 2020 at "Neuro-oncology"

DOI: 10.1093/neuonc/noaa215.118

Abstract: Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain present in most RTKs… read more here.

Keywords: pdgfra; ecdna; growth factor; activation ... See more keywords

STEM-07. CONSERVATION AND FAITHFUL REPRESENTATION OF CIRCULAR EXTRACHROMOSOMAL DNA IN ORTHOTOPIC PATIENT-DERIVED MEDULLOBLASTOMA XENOGRAFTS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.778

Abstract: Abstract BACKGROUND Extrachromosomal DNA (ecDNA) drives tumor heterogeneity and correlates with poor survival across various cancer types. Patient-derived xenograft (PDX) models facilitate preclinical drug testing in vivo, enabling tumor growth analysis and molecular tumor profiling.… read more here.

Keywords: conservation; ecdna; pdx; tumor ... See more keywords

TMIC-26. Intercellular transfer of extrachromosomal DNA in glioblastoma

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.1781

Abstract: Glioblastoma (GBM) represent a complex ecosystem of intertwined interconnections between various cell types. Through diverse mechanisms of intercellular communication, GBM cells can modulate the behavior of both malignant and non-tumor cells, promoting cancer progression. One… read more here.

Keywords: gbm cells; ecdna; tumor; transfer ... See more keywords

Abstract 3130: Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3130

Abstract: Oncogene amplification on extrachromosomal DNA (ecDNA) drives rapid tumor evolution, treatment resistance, and poor outcomes for patients. Computational tools can detect ecDNA in whole-genome sequencing (WGS) data from biopsies. However, the lack of longitudinal studies… read more here.

Keywords: barrett esophagus; cancer; ecdna; extrachromosomal dna ... See more keywords

Abstract 369: In silico investigation of hypoxia and its association with disease outcome and ecDNA detection in TRACERx

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-369

Abstract: Tumors exhibit dynamic gradients of oxygen diffusion and consumption leading to regions of hypoxia. The presence of hypoxia is associated with poor clinical prognosis and elevated genomic instability. Genes can be amplified extrachromosomally as ecDNA,… read more here.

Keywords: detection; disease; ecdna; hypoxia ... See more keywords

Abstract 3754: ecDNAInspector nominates high-confidence structural predictions of extrachromosomal DNA for downstream analysis

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-3754

Abstract: Extrachromosomal DNA (ecDNA) are circular, megabase-scale regions of the genome found outside canonical chromosomes and characterized by high copy-number and frequent oncogene amplification. They are implicated in tumorigenesis, therapeutic resistance, and shortened survival for patients… read more here.

Keywords: cancer; high confidence; analysis; ecdna ... See more keywords

Abstract 3897: Investigating the prevalence of ecDNA in breast cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-3897

Abstract: Extrachromosomal DNA (ecDNA) has been described in multiple cancer types. ecDNAs are circular and are usually greater than 500 base pairs in size. ecDNA structures lack centromeres and thus do not follow the Mendelian mode… read more here.

Keywords: cancer; breast cancer; cell lines; ecdna breast ... See more keywords

Abstract IA017: Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.canevol23-ia017

Abstract: Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA poses one of… read more here.

Keywords: cancer; cancer dynamic; dna ecdna; ecdna ... See more keywords

Association of ERBB2 extrachromosomal DNA (ecDNA) with first-line HER2-targeted treatment outcomes in advanced esophagogastric adenocarcinoma (EGC).

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recommendations! Published in 2024 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2024.42.16_suppl.4041

Abstract: 4041 Background: ecDNA-enabled amplification of oncogenes is associated with increased expression and poor prognosis and is believed to contribute to treatment resistance. However, the prognostic implications of ecDNA amplification on specific targeted therapy outcomes remains… read more here.

Keywords: treatment; egc; ecdna; first line ... See more keywords