Engineered Extracellular Matrices as Biomaterials of Tunable Composition and Function
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201605486
Abstract: Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in regenerative medicine as materials capable to induce cell growth/differentiation and tissue repair by physiological presentation of embedded cues. However, ECM production/decellularization processes and control… read more here.
Keywords: extracellular matrices; composition; ecm; cell ... See more keywords
Extracellular Matrix-Based Strategies for Immunomodulatory Biomaterials Engineering.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801578
Abstract: The extracellular matrix (ECM) is a complex and dynamic structural scaffold for cells within tissues and plays an important role in regulating cell function. Recently it has become appreciated that the ECM contains bioactive motifs… read more here.
Keywords: engineering; immunomodulatory biomaterials; matrix based; extracellular matrix ... See more keywords
Conducting Polymer‐ECM Scaffolds for Human Neuronal Cell Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200941
Abstract: 3D cell culture formats more closely resemble tissue architecture complexity than 2D systems, which are lacking most of the cell–cell and cell–microenvironment interactions of the in vivo milieu. Scaffold‐based systems integrating natural biomaterials are extensively… read more here.
Keywords: cell; ecm; polymer ecm; ecm scaffolds ... See more keywords
MY-1 Loaded Nano-Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early-stage ECM via a Hsp47 Dependent Mechanism.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300332
Abstract: The extracellular matrix (ECM) plays a crucial part in regulating stem cell function through its distinctive mechanical and chemical effect. Therefore, it is worth studying how to activate the driving force of osteoblast cells by… read more here.
Keywords: regeneration; ecm; early stage; nano hydroxyapatite ... See more keywords
The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models
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DOI: 10.1002/advs.202205037
Abstract: Creating a cellular model of Alzheimer's disease (AD) that accurately recapitulates disease pathology has been a longstanding challenge. Recent studies showed that human AD neural cells, integrated into three‐dimensional (3D) hydrogel matrix, display key features… read more here.
Keywords: ecm; disease; alzheimer disease; cellular environment ... See more keywords
Youthful Stem Cell Microenvironments: Rejuvenating Aged Bone Repair Through Mitochondrial Homeostasis Remodeling
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DOI: 10.1002/advs.202409644
Abstract: Extracellular matrix (ECM) derived from mesenchymal stem cells regulates antioxidant properties and bone metabolism by providing a favorable extracellular microenvironment. However, its functional role and molecular mechanism in mitochondrial function regulation and aged bone regeneration… read more here.
Keywords: bmmscs; homeostasis; stem; bone ... See more keywords
Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer
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DOI: 10.1002/advs.202416523
Abstract: The interplay between cancer‐associated fibroblasts (CAFs) and extracellular matrix (ECM) mediates progress, metastasis, and therapy resistance. However, strategy of targeting ECM remodeling to enhance chemosensitivity in ovarian cancer remains elusive. Here, a 22‐gene matrisome signature… read more here.
Keywords: ecm; cancer; enhance chemosensitivity; ovarian cancer ... See more keywords
A new strategy for the decellularization of whole organs by hydrostatic pressure
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3248
Abstract: Tissue engineering has been able to develop novel decellularization‐recellularization techniques, which facilitates the research for the generation of functional organs. This is based in the initial obtention of the organ's extracellular matrix (ECM). Therefore, any… read more here.
Keywords: ecm; new strategy; hydrostatic pressure; decellularization ... See more keywords
The hepatic “matrisome” responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28918
Abstract: The extracellular matrix (ECM) consists of diverse components that work bidirectionally with surrounding cells to create a responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes to the ECM are well recognized and understood. However,… read more here.
Keywords: extracellular matrix; hepatology; responds dynamically; ecm ... See more keywords
Chitosan-placental ECM composite thermos-responsive hydrogel as a biomimetic wound dressing with angiogenic property.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200386
Abstract: Attempts are being made to develop an ideal wound dressing with excellent biomechanical and biological properties. Here, a thermos-responsive hydrogel is fabricated using chitosan (CTS) with various concentrations (1%, 2.5%, and 5% w/v) of solubilized… read more here.
Keywords: ecm; thermos responsive; hydrogel; responsive hydrogel ... See more keywords
Translation Prospects of a Novel ECM‐Silk Fibroin/Alginate 3D‐Printed Scaffold for Treatment of Full‐Thickness Skin Wounds: An In Vitro and In Vivo Study
Sign Up to like & getrecommendations! Published in 2024 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.6637
Abstract: The development of bioinks incorporating extracellular matrix (ECM) has attracted significant interest for creating three‐dimensional (3D)‐printed structures that simulate natural skin, aiming to facilitate profound wound healing. In our study, we utilized the potential of… read more here.
Keywords: full thickness; silk fibroin; skin; ecm ... See more keywords