The role of CD44, hyaluronan and NHE1 in cardiac remodeling
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.08.009
Abstract: ABSTRACT Cardiac remodeling, characterized by excessive extracellular matrix (ECM) remodeling, predisposes the heart to failure if left unresolved. Understanding the signaling mechanisms involved in excessive extracellular matrix (ECM) remodeling is necessary to identify the means… read more here.
Keywords: cardiac remodeling; cd44; role cd44; ecm remodeling ... See more keywords
Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/s41366-018-0005-5
Abstract: Background/Objectives:Obesity is related to a dynamic extracellular matrix (ECM) remodeling, which involves the synthesis and degradation of different proteins, such as tenascin C (TNC) in the adipose tissue (AT). Given the functional relationship between leptin… read more here.
Keywords: inflammation fibrosis; ecm remodeling; leptin; inflammation ... See more keywords
Trabecular meshwork ECM remodeling in glaucoma: could RAS be a target?
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1486822
Abstract: ABSTRACT Introduction: Disturbances of extracellular matrix (ECM) homeostasis in trabecular meshwork (TM) cause increased aqueous outflow resistance leading to elevated intraocular pressure (IOP) in glaucomatous eyes. Therefore, restoration of ECM homeostasis is a rational approach… read more here.
Keywords: ecm homeostasis; trabecular meshwork; ecm remodeling;
T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-1012
Abstract: Chemotherapy induces prometastatic pulmonary ECM remodeling by upregulating LOX in T cells, which can be targeted with LOX inhibitors to suppress metastasis. Metastasis is the main cause of cancer-related mortality. Despite intense efforts to understand… read more here.
Keywords: chemotherapy; ecm remodeling; metastasis; cancer ... See more keywords
Pyruvate Mediates ECM Remodeling in the Lung Metastatic Niche.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-034
Abstract: Pyruvate drives collagen hydroxylation in the extracellular matrix to support breast cancer metastasis. read more here.
Keywords: pyruvate mediates; ecm remodeling; lung metastatic; pyruvate ... See more keywords
ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073709
Abstract: Current therapeutic strategies for gastric cancer, including surgery and chemotherapy improve patient survival; however, the survival rate of patients with metastatic gastric cancer is very low. The molecular mechanisms underlying the dissemination of gastric cancer… read more here.
Keywords: ecm remodeling; related genes; cancer; gastric cancer ... See more keywords
Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911378
Abstract: Lysyl oxidases have long been considered key secreted extracellular matrix modifying enzymes. As such, their activity has been associated with the crosslinking of collagens and elastin, and as a result, they have been linked to… read more here.
Keywords: ecm remodeling; oxidases orchestrators; behavior ecm; cellular behavior ... See more keywords
Epigallocatechin gallate attenuates overload‑induced cardiac ECM remodeling via restoring T cell homeostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7018
Abstract: It has previously been demonstrated that Epigallocatechin gallate (EGCG) has regulatory effects on cellular immunity. The present study explored whether EGCG inhibits the overload‑induced cardiac extracellular matrix (ECM) remodeling through targeting the balance of T cell subpopulations.… read more here.
Keywords: induced cardiac; ecm remodeling; epigallocatechin gallate; overload induced ... See more keywords
The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72853
Abstract: Rationale: Patients with colorectal cancer die mainly due to liver metastases (CRC-LM). Although the tumor microenvironment (TME) plays an important role in tumor development and therapeutic response, our understanding of the individual TME components, especially… read more here.
Keywords: ecm remodeling; liver; cafs; single cell ... See more keywords