Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4274
Abstract: Human neutrophil elastase (hNE) is an abundant serine protease that is a major constituent of lung elastolytic activity. However, when secreted in excess, if not properly attenuated by selective inhibitor proteins, it can have detrimental… read more here.
Keywords: ecotin; inhibition; sequence; neutrophil elastase ... See more keywords
Structural basis for the inhibition mechanism of ecotin against neutrophil elastase by targeting the active site and secondary binding site.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00493
Abstract: Human neutrophil elastase (hNE) is a serine protease that plays a major role in defending the bacterial infection. However, elevated expression of hNE is reported in lung and breast cancer, among others. Moreover, hNE is… read more here.
Keywords: ecotin; binding site; inhibition; site ... See more keywords