An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.02.051
Abstract: SUMMARY ECSIT is a mitochondrial complex I (CI)-associated protein that has been shown to regulate the production of mitochondrial reactive oxygen species (mROS) following engagement of Toll-like receptors (TLRs). We have generated an Ecsit conditional… read more here.
Keywords: ecsit mitochondrial; ecsit; mitochondrial complex; role ecsit ... See more keywords
ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1110369
Abstract: Introduction Estrogens inhibit bone resorption and preserve bone mass, at least in part, via direct effects on osteoclasts. The binding of RANKL, the critical cytokine for osteoclast differentiation, to its receptor in osteoclast precursor cells… read more here.
Keywords: stimulation mitochondria; ecsit; effects rankl;
HBHA-ECSIT interaction disrupts macrophage autophagy to promote Mycobacterium tuberculosis persistence
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1596568
Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the most significant global health challenges exacerbated by latent tuberculosis infection (LTBI). Heparin-binding hemagglutinin (HBHA), a virulence factor of Mtb, plays a critical role in… read more here.
Keywords: ecsit; persistence; mycobacterium tuberculosis; hbha ... See more keywords