Development of a fast CE method for high throughput screening of ecto‐5′‐nucleotidase inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800105
Abstract: Overexpression of ecto‐5′‐nucleotidase is found to be linked to cancer progression and other diseases which makes screening of its inhibitors on demand. Unfortunately, there is scarcity of reported ecto‐5′‐nucleotidase inhibitors because of unavailability of simple,… read more here.
Keywords: nucleotidase inhibitors; ecto nucleotidase; high throughput; screening ecto ... See more keywords
Increased Ap4A levels and ecto-nucleotidase activity in glaucomatous mice retina
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9612-9
Abstract: The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of degradation machinery through ecto-nucleotidase activity… read more here.
Keywords: ecto nucleotidase; pathology; nucleotidase activity; activity ... See more keywords
Persistent increase in ecto‑5'‑nucleotidase activity from encephala of adult zebrafish exposed to ethanol during early development.
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2018.10.004
Abstract: Prenatal alcohol exposure causes alterations to the brain and can lead to numerous cognitive and behavioral outcomes. Long-lasting effects of early ethanol exposure have been registered in glutamatergic and dopaminergic systems. The purinergic system has… read more here.
Keywords: exposed ethanol; ecto nucleotidase; exposure; nucleotidase activity ... See more keywords
Identification and validation of ecto-5' nucleotidase as an immunotherapeutic target in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2022 at "Blood cancer journal"
DOI: 10.1038/s41408-022-00635-3
Abstract: Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and adaptive immune responses. Defining… read more here.
Keywords: nucleotidase immunotherapeutic; validation ecto; multiple myeloma; identification validation ... See more keywords
Appraisal of novel azomethine–thioxoimidazolidinone conjugates as ecto-5′-nucleotidase inhibitors: synthesis and molecular docking studies
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02675a
Abstract: Purinergic signaling is regulated by a group of extracellular enzymes called ectonucleotidases. One of its members i.e., ecto-5′-nucleotidase (h-e5′NT) is involved in the final step of the enzymatic hydrolysis cascade that is the conversion of… read more here.
Keywords: molecular docking; novel azomethine; ecto nucleotidase; appraisal novel ... See more keywords
The Ecto-5′nucleotidase/CD73 Mediates Leishmania amazonensis Survival in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/9928362
Abstract: Endogenous nucleotides produced by various group of cells under inflammatory conditions act as potential danger signals in vivo. Extracellularly released nucleotides such as ATP are rapidly hydrolyzed to adenosine by the coordinated ectonucleotidase activities of… read more here.
Keywords: cd73; ecto nucleotidase; nucleotidase cd73; cd39 cd73 ... See more keywords
Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
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DOI: 10.1371/journal.pone.0223892
Abstract: 2'-Deoxyadenosine 5'-monophosphate (dAMP), a deoxyribonucleotide found in DNA, affects intestinal cell growth. The molecular mechanisms underlying gastrointestinal absorption of foreign DNA ingested along with food has hardly been investigated. The aim of this study was… read more here.
Keywords: nucleoside transporter; ecto nucleotidase; nucleotidase cd73; uptake damp ... See more keywords
Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge
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DOI: 10.3390/biom12050697
Abstract: Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required… read more here.
Keywords: allergen challenge; lack ecto; ecto nucleotidase; sensitized mice ... See more keywords