Epigallocatechin-3-gallate downregulates lipopolysaccharide signaling in human aortic endothelial cells by inducing ectodomain shedding of TLR4.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172692
Abstract: Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea leaves, has anti-inflammatory effects. In this study, we investigated the mechanism by which EGCG attenuates the effects of lipopolysaccharides (LPS), an agonist of toll-like receptor 4… read more here.
Keywords: shedding tlr4; ectodomain shedding; epigallocatechin gallate; egcg ... See more keywords
Protein-Labeling Fluorescent Probe Reveals Ectodomain Shedding of Transmembrane Carbonic Anhydrases.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00679
Abstract: Ectodomain shedding is a form of limited proteolysis in which a protease cleaves a transmembrane protein, releasing the extracellular domain from the cell surface. Cells use this process to regulate a wide variety of biological… read more here.
Keywords: protein labeling; ectodomain shedding; carbonic anhydrases; cell surface ... See more keywords
MET ectodomain shedding is associated with poor disease-free survival of patients diagnosed with oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0426-2
Abstract: Ectodomain shedding unleashes the aggressive nature of the MET oncogene product. Using specific C- and N-terminal MET antibodies (D1C2 and A2H2-3), MET protein status (i.e., no MET, decoy MET, transmembranous C-terminal MET with or without… read more here.
Keywords: cell carcinoma; squamous cell; oral squamous; ectodomain shedding ... See more keywords
Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0140
Abstract: Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signaling molecules. Of importance for disease is the release of ligands that activate the EGFR, such as TGFα, which is mostly carried out by… read more here.
Keywords: genomics approach; functional genomics; ectodomain shedding; egfr ligand ... See more keywords
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280448
Abstract: Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events. Because compounds that act on TRP channels are potential candidates for therapeutic agents, a simple… read more here.
Keywords: activation; ectodomain shedding; trp channel; trp channels ... See more keywords
Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2004
Abstract: Epithin/PRSS14 is a membrane serine protease that plays a key role in tumor progression. The protease exists on the cell surface until its ectodomain shedding, which releases most of the extracellular domain. Previously, we showed… read more here.
Keywords: epithin prss14; ectodomain shedding; prss14; domain ... See more keywords
System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.72947
Abstract: Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. DR is a multifactorial disease involving changes in retinal microvasculature and neuronal layers, and aberrations in vascular endothelial growth factors… read more here.
Keywords: ectodomain shedding; vitreous proteome; diabetic retinopathy; angiogenesis ... See more keywords