Ectoine lozenges in the treatment of acute viral pharyngitis: a prospective, active-controlled clinical study
Sign Up to like & getrecommendations! Published in 2019 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-019-05324-9
Abstract: PurposeAcute pharyngitis is an uncomfortable disorder mostly caused by viruses and for which antibiotics are unwarranted. This study compared lozenges containing ectoine, a natural extremolyte, with hyaluronic acid lozenges and hypertonic saline gargle for symptomatic… read more here.
Keywords: ectoine; pharyngitis; hyaluronic acid; saline gargle ... See more keywords
Promoter engineering for high ectoine production in a lower saline medium by Halomonas hydrothermalis Y2.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology letters"
DOI: 10.1007/s10529-021-03084-3
Abstract: OBJECTIVES For the stress from fermenters, downstream processing equipment, and wastewater treatment to be alleviated, lowering salt-dependence in the ectoine synthesis process is of great significance in the moderately halotolerant Halomonas hydrothermalis Y2. RESULTS In… read more here.
Keywords: halomonas hydrothermalis; ectoine synthesis; lower saline; promoter ... See more keywords
The Potential of Ectoine as a Brain Anti-Aging Agent in Rat Model of d-Galactose-Accelerated Aging May Be Mediated Through Crosstalk Between Redox/Mitochondrial Homeostasis/Autophagic/Apoptotic Pathways
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05451-x
Abstract: Aging has emerged as a prominent area of academic inquiry. Brain aging is a complex physiological process characterized by features such as enhanced apoptosis, oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired autophagy. Currently, effective preventative… read more here.
Keywords: brain aging; accelerated aging; brain; aging agent ... See more keywords
High Ectoine Production from Lignocellulosic Hydrolysate by Escherichia coli through Metabolic and Fermentation Engineering.
Sign Up to like & getrecommendations! Published in 2025 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.4c00899
Abstract: Ectoine, a major compatible solute in halophilic micro-organisms, shows great potential in cosmetics and pharmaceuticals areas owing to its water-binding properties and capability to prevent oxidative damage. In this study, the ectABC gene cluster responsible… read more here.
Keywords: escherichia coli; ectoine; fermentation; lignocellulosic hydrolysate ... See more keywords
Metabolic pathway engineering of high-salinity-induced overproduction of L-proline improves high-salinity stress tolerance of an ectoine-deficient Halomonas elongata
Sign Up to like & getrecommendations! Published in 2024 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01195-24
Abstract: ABSTRACT Halophilic bacteria have adapted to survive in high-salinity environments by accumulating amino acids and their derivatives as organic osmolytes. L-Proline (Pro) is one such osmolyte that is also being used as a feed stimulant… read more here.
Keywords: salinity; ectoine; halomonas elongata; elongata hn6 ... See more keywords
High ectoine production by an engineered Halomonas hydrothermalis Y2 in a reduced salinity medium
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1230-x
Abstract: BackgroundAs an attracted compatible solute, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (ectoine) showed great potentials in various field. However, lower productivity and high saline medium seriously hinder its wide applications.ResultsThe entire ectoine metabolism, including pathways for ectoine synthesis and… read more here.
Keywords: production; medium; doea; salinity ... See more keywords
Elucidating the salt-tolerant mechanism of Halomonas cupida J9 and unsterile ectoine production from lignocellulosic biomass
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Cell Factories"
DOI: 10.1186/s12934-024-02515-w
Abstract: Ectoine as an amino acid derivative is widely applied in many fields, such as the food industry, cosmetic manufacturing, biologics, and therapeutic agent. Large-scale production of ectoine is mainly restricted by the cost of fermentation… read more here.
Keywords: j9u p8ec; production ectoine; ectoine; halomonas cupida ... See more keywords
Adaptation to Varying Salinity in Halomonas elongata: Much More Than Ectoine Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.846677
Abstract: The halophilic γ-proteobacterium Halomonas elongata DSM 2581T thrives at salt concentrations well above 10 % NaCl (1.7 M NaCl). A well-known osmoregulatory mechanism is the accumulation of the compatible solute ectoine within the cell in… read more here.
Keywords: adaptation; halomonas elongata; accumulation; ectoine accumulation ... See more keywords
Metabolic engineering of Halomonas elongata: Ectoine secretion is increased by demand and supply driven approaches
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.968983
Abstract: The application of naturally-derived biomolecules in everyday products, replacing conventional synthetic manufacturing, is an ever-increasing market. An example of this is the compatible solute ectoine, which is contained in a plethora of treatment formulations for… read more here.
Keywords: supply driven; halomonas elongata; demand; ectoine ... See more keywords
Application of Biotechnology and Chiral Technology Methods in the Production of Ectoine Enantiomers
Sign Up to like & getrecommendations! Published in 2024 at "Applied Sciences"
DOI: 10.3390/app14188353
Abstract: Natural ectoine, (+)-(4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid, is an extremely important small biomolecule belonging to the class of osmolytic/osmoprotective compounds. It stabilizes biomacromolecules such as DNA and proteins and protects them from denaturation by heat, dehydration, and UV… read more here.
Keywords: application biotechnology; chiral technology; ectoine; biotechnology chiral ... See more keywords
Exploring the Therapeutic Potential of Ectoine in Duchenne Muscular Dystrophy: Comparison with Taurine, a Supplement with Known Beneficial Effects in the mdx Mouse
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179567
Abstract: Duchenne Muscular Dystrophy (DMD) is a debilitating muscle disorder that condemns patients to year-long dependency on glucocorticoids. Chronic glucocorticoid use elicits many unfavourable side-effects without offering satisfying clinical improvement, thus, the search for alternative treatments… read more here.
Keywords: duchenne muscular; mdx mice; mdx mouse; ectoine ... See more keywords