Ectopic Calcification and Hypophosphatemic Rickets: Natural History of ENPP1 and ABCC6 Deficiencies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4418
Abstract: Generalized arterial calcification of infancy (GACI) is a rare disorder caused by ENPP1 or ABCC6 variants. GACI is characterized by low pyrophosphate, arterial calcification, and high mortality during the first year of life, but the… read more here.
Keywords: ectopic calcification; abcc6 deficiencies; calcification; hypophosphatemic rickets ... See more keywords
The Effects of Progenitor and Differentiated Cells on Ectopic Calcification of Engineered Vascular Tissues.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.08.019
Abstract: Ectopic vascular calcification associated with aging, diabetes mellitus, atherosclerosis, and chronic kidney disease is a considerable risk factor for cardiovascular events and death. Although vascular smooth muscle cells are primarily implicated in calcification, the role… read more here.
Keywords: vascular tissues; ectopic calcification; calcification engineered; calcification ... See more keywords
Relationship between intact parathyroid hormone and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease: A retrospective study.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.108926
Abstract: AIM We aimed to investigate the relationship between intact parathyroid hormone (iPTH) levels and all-cause death, cardiovascular events, and ectopic calcification in patients with diabetic kidney disease (DKD). METHODS In this retrospective cohort study, we… read more here.
Keywords: death cardiovascular; ectopic calcification; cause death; calcification ... See more keywords
Association between intermittent administration of parathyroid hormone 1-34 and ectopic calcification in rats
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.16298.1
Abstract: The present study was conducted to determine the association between parathyroid hormone 1-34 administration and ectopic calcification in rats with glucocorticoid induced osteoporosis. A total of 18 rats were used in the current study. Osteoporosis… read more here.
Keywords: parathyroid hormone; calcification rats; administration; ectopic calcification ... See more keywords
ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010192
Abstract: Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are clinically distinct genetic entities of ectopic calcification associated with differentially reduced circulating levels of inorganic pyrophosphate (PPi), a potent endogenous inhibitor of calcification. Variants… read more here.
Keywords: calcification; enpp1 variants; genetic heterogeneity; ectopic calcification ... See more keywords
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-16
Abstract: Vascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyperphosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs)… read more here.
Keywords: calcification; hydroxyvitamin hydroxylase; cyp27b1; high phosphate ... See more keywords
ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094555
Abstract: Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and… read more here.
Keywords: ectopic calcification; pyrophosphate ectopic; pxe; abcc6 pyrophosphate ... See more keywords
Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031838
Abstract: Pseudoxanthoma elasticum (PXE) is an intractable Mendelian disease characterized by ectopic calcification in skin, eyes and blood vessels. Recently, increased activation of the DNA damage response (DDR) was shown to be involved in PXE pathogenesis,… read more here.
Keywords: minocycline; concept study; proof concept; calcification ... See more keywords
Mitochondrial Dysfunction and Oxidative Stress in Hereditary Ectopic Calcification Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315288
Abstract: Ectopic calcification (EC) is characterized by an abnormal deposition of calcium phosphate crystals in soft tissues such as blood vessels, skin, and brain parenchyma. EC contributes to significant morbidity and mortality and is considered a… read more here.
Keywords: mitochondrial dysfunction; oxidative stress; dysfunction oxidative; ectopic calcification ... See more keywords
Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043366
Abstract: Ectopic calcification refers to the pathological accumulation of calcium ions in soft tissues and is often the result of a dysregulated action or disrupted function of proteins involved in extracellular matrix mineralization. While the mouse… read more here.
Keywords: calcium; calcification; ectopic calcification; zebrafish models ... See more keywords