Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2016.11.008
Abstract: Chinese hamster ovary (CHO) cells are the preferred cell factory for the production of therapeutic glycoproteins. Although efforts primarily within bioprocess optimization have led to increased product titers of recombinant proteins (r-proteins) expressed in CHO… read more here.
Keywords: effector genes; hamster ovary; chinese hamster; ectopic expression ... See more keywords
Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO)
Sign Up to like & getrecommendations! Published in 2019 at "Bone Reports"
DOI: 10.1016/j.bonr.2018.100192
Abstract: Tumor-induced rickets/osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumors that ectopically express fibroblast growth factor 23 (FGF23). FGF23 is a bone-derived hormone that regulates serum phosphate concentrations. Patients with TIO develop hypophosphatemic rickets/osteomalacia… read more here.
Keywords: fgf23; rickets osteomalacia; expression klotho; ectopic expression ... See more keywords
3144 – ECTOPIC EXPRESSION OF THE HOMEOBOX GENE MNX1 IS THE TRANSFORMING EVENT IN A MOUSE MODEL OF PEDIATRIC T(7;12)(Q36;P13) PEDIATRIC ACUTE MYELOID LEUKEMIA
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.151
Abstract: Pediatric acute myeloid leukemia (AML) with the translocation t(7;12)(q36;p13) is a form of childhood leukemia associated with inferior outcome. In the current investigation we have studied the gene alterations that are induced by this chromosomal… read more here.
Keywords: leukemia; ectopic expression; gene; mnx1 etv6 ... See more keywords
Ectopic expression of T in the paraxial mesoderm disrupts somite maturation in the mouse.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental biology"
DOI: 10.1016/j.ydbio.2022.02.010
Abstract: T is the founding member of the T-box family of transcription factors; family members are critical for cell fate decisions and tissue morphogenesis throughout the animal kingdom. T is expressed in the primitive streak and… read more here.
Keywords: mesoderm; expression; mouse; tbx15 tbx18 ... See more keywords
Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204071119
Abstract: Significance This work originated from mining of cancer genome data and proceeded to analyze the effects of ectopic expression of meiotic cohesins in mitotic cells in culture. In the process, apart from conclusively answering the… read more here.
Keywords: ectopic expression; cohesin; expression meiotic; instability ... See more keywords
Ectopic expression of a cell-wall degrading enzyme induced OsAP2/ERF152, leads to resistance against bacterial and fungal infection in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2020 at "Phytopathology"
DOI: 10.1094/phyto-10-19-0395-r
Abstract: Pathogen secreted cell wall degrading enzymes (CWDEs) induce plant innate immune responses. The expression of rice transcription factor, APETALA2/Ethylene response factor-152 (OsAP2/ERF152) is enhanced in leaves upon treatment with different CWDEs and upon wounding. Ectopic… read more here.
Keywords: expression; arabidopsis; ectopic expression; osap2 erf152 ... See more keywords
Ectopic Expression of WUSCHEL (AtWUS) Gene Alters Plant Growth and Development in Rice
Sign Up to like & getrecommendations! Published in 2020 at "Planta"
DOI: 10.11648/j.plant.20200803.11
Abstract: Developmental genes (DG)/ morphogenic genes are involved in enhancing the transformation and regeneration of plants. One such DG is the WUSCHEL (WUS) gene, a homeodomain transcription factor, and is involved in the stem cell maintenance… read more here.
Keywords: atwus gene; wus gene; ectopic expression; wus ... See more keywords
SHISA3, an antagonist of the Wnt/β-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0236192
Abstract: Breast cancer (BC) is the foremost cause of cancer related deaths in women globally. Currently there is a scarcity of reliable biomarkers for its early stage diagnosis and theranostics monitoring. Altered DNA methylation patterns leading… read more here.
Keywords: shisa3; shisa3 antagonist; breast cancer; expression ... See more keywords
Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1110271
Abstract: Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system, but the mechanisms driving this response remain unclear. In this study, we conducted “pseudoviral infection” of SARS-CoV-2 subunits to evaluate their toxic… read more here.
Keywords: contractile function; metabolic profiles; ectopic expression; sars cov ... See more keywords
Ectopic expression of Nav1.7 in spinal dorsal horn neurons induced by NGF contributes to neuropathic pain in a mouse spinal cord injury model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1091096
Abstract: Neuropathic pain (NP) induced by spinal cord injury (SCI) often causes long-term disturbance for patients, but the mechanisms behind remains unclear. Here, our study showed SCI-induced ectopic expression of Nav1.7 in abundant neurons located in… read more here.
Keywords: ectopic expression; sci; expression nav1; dorsal ... See more keywords
Ectopic Expression of VvSUC27 Induces Stenospermocarpy and Sugar Accumulation in Tomato Fruits
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.759047
Abstract: Seedless fruits are favorable in the market because of their ease of manipulation. Sucrose transporters (SUTs or SUCs) are essential for carbohydrate metabolism in plants. Whether SUTs participate directly in causing stenospermocarpy, thereby increasing fruit… read more here.
Keywords: carbohydrate metabolism; vvsuc27; overexpressing lines; expression vvsuc27 ... See more keywords