Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
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DOI: 10.1038/s41467-020-16795-4
Abstract: Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 signaling as an inducer of fat… read more here.
Keywords: integrin signaling; ectopic lipid; fatty acid; insulin resistance ... See more keywords
Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment.
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DOI: 10.1530/endoabs.81.p657
Abstract: OBJECTIVES Insulin resistance is associated with ectopic lipid deposition. Growth hormone (GH) status also modulates ectopic lipid accumulation, but how this associates with insulin resistance in patients with GH disorders is not well established. DESIGN… read more here.
Keywords: insulin resistance; resistance; lipid deposition; ectopic lipid ... See more keywords
ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition
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DOI: 10.3389/fendo.2022.927763
Abstract: Background Ectopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs. Studies have shown that serum… read more here.
Keywords: angptl8; ectopic lipid; deposition; differentiation ... See more keywords
Ectopic lipid metabolism in anterior pituitary dysfunction
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DOI: 10.3389/fendo.2023.1075776
Abstract: Over the past decades, adapted lifestyle and dietary habits in industrialized countries have led to a progress of obesity and associated metabolic disorders. Concomitant insulin resistance and derangements in lipid metabolism foster the deposition of… read more here.
Keywords: metabolism; metabolism anterior; lipid metabolism; ectopic lipid ... See more keywords