An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice
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DOI: 10.1002/jbmr.3227
Abstract: The potent cathepsin K (CatK) inhibitor, Tanshinone IIA sulfonic sodium (T06), was tested for its in vitro and in vivo antiresorptive activities. T06 binds in an ectosteric site of CatK remote from its active site… read more here.
Keywords: inhibitor; bone resorption; cathepsin; site ... See more keywords