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   Articles with "edaravone" as a keyword



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Edaravone Administered Orally and Via Nasogastric Tube in Healthy Adults: A Comparative Bioavailability Phase 1 Study

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1175

Abstract: Intravenous edaravone is used to treat patients with amyotrophic lateral sclerosis. This randomized, open‐label, two‐way crossover, single‐dose phase 1 study compared the relative bioavailability of a newly developed edaravone oral suspension when administered orally and… read more here.

Keywords: orally via; bioavailability; phase study; tube ... See more keywords
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Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults

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recommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.925

Abstract: Intravenous (IV) edaravone is approved as an amyotrophic lateral sclerosis (ALS) treatment. Because IV administration places a burden on patients, development of orally administered ALS treatments is needed. Therefore, 2 phase 1 studies of oral… read more here.

Keywords: formulation; edaravone healthy; drug; edaravone ... See more keywords
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Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signaling.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.10.165

Abstract: Pulmonary fibrosis is responsible for the both short-term and long-term outcomes in patients with acute respiratory distress syndrome (ARDS). There is still no effective cure to improve prognosis. The purpose of this study was to… read more here.

Keywords: fibrosis; associated early; smad3 signaling; pulmonary fibrosis ... See more keywords
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Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.12.035

Abstract: We used a multimodal approach to evaluate the effects of edaravone in a rat model of spinal cord injury (SCI). SCI was induced by extradural compression of thoracic spinal cord. In experiment 1, 30 min prior… read more here.

Keywords: dose edaravone; moderate dose; edaravone; spinal cord ... See more keywords
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Edaravone reduces A&bgr;‐induced oxidative damage in SH‐SY5Y cells by activating the Nrf2/ARE signaling pathway

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recommendations! Published in 2019 at "Life Sciences"

DOI: 10.1016/j.lfs.2019.02.025

Abstract: Aims: Edaravone potentially alleviates cognitive deficits in a mouse model of Alzheimer's disease (AD). However, the mechanism of edaravone in suppressing AD progression remains unclear. We aim to investigate the mechanism of edaravone in suppressing… read more here.

Keywords: oxidative damage; nrf2 signaling; signaling pathway; bgr induced ... See more keywords
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A novel brain targeted plasma exosomes enhance the neuroprotective efficacy of edaravone in ischemic stroke.

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recommendations! Published in 2021 at "IET nanobiotechnology"

DOI: 10.1049/nbt2.12003

Abstract: Ischemic stroke is often involved in the excessive production of reactive oxygen species (ROS), which aggravate ischemic injury. Edaravone (EDV) as an efficient free radical scavenger has demonstrated the effective neuroprotective effects in the therapy… read more here.

Keywords: ischemic stroke; edv; edaravone; brain ... See more keywords
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Edaravone administration in pivotal clinical Study 19

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recommendations! Published in 2019 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"

DOI: 10.1080/21678421.2019.1582672

Abstract: Recently, ALSFTD published an editorial entitled “Is edaravone harmful? (A placebo is not a control)” (1). The editorial questioned whether the mode of administration of study drug in pivotal Study 19 affected the disease trajectory… read more here.

Keywords: administration; study; decline; study drug ... See more keywords
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Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000019316

Abstract: Abstract Objective: To investigate the effect of edaravone on depression relief in symptomatic patients with intracranial stenosis and its relationship with the expression of sex hormones. Methods: We recruited 112 patients with symptomatic intracranial arterial… read more here.

Keywords: edaravone; treatment; stenosis; experimental group ... See more keywords
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Edaravone combined with Shuxuening versus edaravone alone in the treatment of acute cerebral infarction: A systematic review and meta-analysis

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recommendations! Published in 2023 at "Medicine"

DOI: 10.1097/md.0000000000032929

Abstract: Background: Shuxuening injection (SXN) is a traditional Chinese medicine used in the treatment of cardiovascular diseases. Whether it can provide better outcomes when combined with edaravone injection (ERI) for the treatment of acute cerebral infarction… read more here.

Keywords: treatment; cerebral infarction; edaravone; medicine ... See more keywords
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Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke

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recommendations! Published in 2021 at "Stroke"

DOI: 10.1161/strokeaha.120.031197

Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone and (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects of antioxidant and… read more here.

Keywords: edaravone; dexborneol versus; versus edaravone; day ... See more keywords
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Keap1-Nrf2/ARE Pathway-based Investigation into the Mechanism of Edaravone Dexborneol in Cerebral Infarction Model Neuroprotection.

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recommendations! Published in 2022 at "Cellular and molecular biology"

DOI: 10.14715/cmb/2022.68.9.16

Abstract: The neuroprotection of acute cerebral infarction (ACI) model by edaravone dexborneol (ED)-mediated Keap1-Nrf2/ARE signal pathway was investigated. Sham operation was set as a control to prepare the ACI model with cerebral artery occlusion. The abdominal… read more here.

Keywords: keap1 nrf2; group; model; cerebral infarction ... See more keywords