Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-02-765206
Abstract: Deficiency of factor X (F10) in humans is a rare bleeding disorder with a heterogeneous phenotype and limited therapeutic options. Targeted disruption of F10 and other common pathway factors in mice results in embryonic/neonatal lethality… read more here.
Keywords: genome editing; editing factor; f10; common pathway ... See more keywords