CRISPR-based genome editing in primary human pancreatic islet cells
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DOI: 10.1038/s41467-021-22651-w
Abstract: Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and… read more here.
Keywords: genome editing; crispr based; islet; editing primary ... See more keywords
Abstract 785: Application of CRISPR/Cas9 gene editing to primary T cells
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DOI: 10.1158/1538-7445.am2018-785
Abstract: T cells mediate a broad range of immune responses, especially generation of adaptive immunity for cancer cell clearance. Identification of genetic components that modulate T cell proliferation, differentiation, migration and cytotoxicity would facilitate development of… read more here.
Keywords: crispr cas9; editing primary; primary cells; gene ... See more keywords
Genome editing for primary immunodeficiencies: A therapeutic perspective on Wiskott-Aldrich syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.966084
Abstract: Primary immunodeficiency diseases (PIDs) are a group of rare inherited disorders affecting the immune system that can be conventionally treated with allogeneic hematopoietic stem cell transplantation and with experimental autologous gene therapy. With both approaches… read more here.
Keywords: genome editing; aldrich syndrome; primary immunodeficiencies; editing primary ... See more keywords