Enabling large-scale genome editing at repetitive elements by reducing DNA nicking
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DOI: 10.1093/nar/gkaa239
Abstract: Abstract To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of… read more here.
Keywords: large scale; genome editing; repetitive elements; scale genome ... See more keywords