Genome editing technologies, mechanisms and improved production of therapeutic phytochemicals: Opportunities and prospects
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28260
Abstract: Plants produce a large number of secondary metabolites, known as phytometabolites that may be employed as medicines, dyes, poisons, and insecticides in the field of medicine, agriculture, and industrial use, respectively. The rise of genome… read more here.
Keywords: genome editing; production therapeutic; technologies mechanisms; editing technologies ... See more keywords
Developments in Hematopoietic Stem Cell Expansion and Gene Editing Technologies.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2017_114
Abstract: Hematopoietic stem cells (HSCs) are rare cells, which housed in the adult bone marrow. They maintain all types of differentiated blood cells throughout life. Due to limited availability of HSCs for transplantation, treatment of various… read more here.
Keywords: gene editing; expansion; expansion gene; editing technologies ... See more keywords
Development of genome-editing technologies for plant pathogenic fungi
Sign Up to like & getrecommendations! Published in 2020 at "Journal of General Plant Pathology"
DOI: 10.1007/s10327-020-00956-w
Abstract: In this study, we focused on the DSB repair machinery as a mechanism of asexual pathogenic and genomic evolution in P. oryzae. Using the fungal TALEN system, we demonstrated that DSBs trigger genome rearrangement with… read more here.
Keywords: genome editing; pathogenic fungi; editing technologies; plant pathogenic ... See more keywords
Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-017-0417-7
Abstract: Purpose of ReviewIn this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy.Recent FindingsEngineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in… read more here.
Keywords: cell immunotherapy; adoptive cell; editing technologies; cancer ... See more keywords
Framing and legitimating EU legal regulation of human gene-editing technologies: key facets and functions of an imaginary
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsaa080
Abstract: ABSTRACT Gene-editing technologies, ie those able to make changes in the DNA of an organism, are the object of global competition and a regulatory race between countries and regions. There is an attempt to craft… read more here.
Keywords: gene editing; editing technologies; legal regulation; regulation human ... See more keywords
High-throughput methods for genome editing: the more the better.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac017
Abstract: During the last decade, targeted genome-editing technologies, especially clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (CRISPR/Cas) technologies, have permitted efficient targeting of genomes, thereby modifying these genomes to offer tremendous opportunities for deciphering gene… read more here.
Keywords: genome editing; crispr; high throughput; throughput genome ... See more keywords
Genome Editing Technologies as Cellular Defense Against Viral Pathogens
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.716344
Abstract: Viral infectious diseases are significant threats to the welfare of world populations. Besides the widespread acute viral infections (e.g., dengue fever) and chronic infections [e.g., those by the human immunodeficiency virus (HIV) and hepatitis B… read more here.
Keywords: viral pathogens; genome editing; infectious diseases; editing technologies ... See more keywords
Gene-Editing Technologies and Applications in Legumes: Progress, Evolution, and Future Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.859437
Abstract: Legumes are rich in protein and phytochemicals and have provided a healthy diet for human beings for thousands of years. In recognition of the important role they play in human nutrition and agricultural production, the… read more here.
Keywords: genome editing; applications legumes; gene editing; technologies applications ... See more keywords
Base Editing in Plants: Applications, Challenges, and Future Prospects
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.664997
Abstract: The ability to create targeted modifications in the genomes of plants using genome editing technologies has revolutionized research in crop improvement in the current dispensation of molecular biology. This technology has attracted global attention and… read more here.
Keywords: base editing; plants applications; editing plants; editing technologies ... See more keywords
Application of CRISPR/Cas Technology in Spermatogenesis Research and Male Infertility Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061000
Abstract: As the basis of animal reproductive activity, normal spermatogenesis directly determines the efficiency of livestock production. An in-depth understanding of spermatogenesis will greatly facilitate animal breeding efforts and male infertility treatment. With the continuous development… read more here.
Keywords: spermatogenesis; gene editing; infertility treatment; editing technologies ... See more keywords
Gene Editing Technologies to Target HBV cccDNA
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14122654
Abstract: Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. Current licensed therapies against HBV efficiently suppress viral… read more here.
Keywords: hbv cccdna; gene editing; target hbv; editing technologies ... See more keywords