Gene editing provides a tool to investigate genes involved in reproduction of pigs.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular reproduction and development"
DOI: 10.1002/mrd.23620
Abstract: CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection of guide RNAs (gRNA) designed… read more here.
Keywords: crispr cas9; gene editing; cas9 gene; editing technology ... See more keywords
Base editing in rice: current progress, advances, limitations, and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Plant cell reports"
DOI: 10.1007/s00299-020-02656-3
Abstract: KEY MESSAGE Base editing is one of the promising genome editing tools for generating single-nucleotide changes in rice genome. Rice (Oryza sativa L.) is an important staple food crop, feeding half of the population around… read more here.
Keywords: base editing; genome editing; editing rice; rice ... See more keywords
Sharpening the Molecular Scissors: Advances in Gene-Editing Technology
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.100789
Abstract: The ability to precisely modify human genes has been made possible by the development of tools such as meganucleases, zinc finger nucleases, TALENs, and CRISPR/Cas. These now make it possible to generate targeted deletions, insertions,… read more here.
Keywords: gene editing; editing technology; gene; cas9 ... See more keywords
Gene editing technology: Towards precision medicine in inherited retinal diseases
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in Ophthalmology"
DOI: 10.1080/08820538.2021.1887903
Abstract: ABSTRACT Purpose: To review preclinical and clinical advances in gene therapy, with a focus on gene editing technologies, and application to inherited retinal disease. Methods: A narrative overview of the literature, summarizing the state-of-the-art in… read more here.
Keywords: medicine; gene editing; disease; editing technology ... See more keywords
Applications of CRISPR genome editing technology in drug target identification and validation
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1317244
Abstract: ABSTRACT Introduction: The analysis of pharmaceutical industry data indicates that the major reason for drug candidates failing in late stage clinical development is lack of efficacy, with a high proportion of these due to erroneous… read more here.
Keywords: genome editing; target; drug; editing technology ... See more keywords
ORFV can carry TRAP gene expression via intracellular CRISPR/Cas9 gene editing technology.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of virological methods"
DOI: 10.2139/ssrn.4120630
Abstract: Orf is an acute and highly contracted human and animal infection caused by orf virus (ORFV), which mainly affects sheep, goats, and other species. Clinically, opportunistic or conditional pathogens such as Staphylococcus aureus (S. aureus)… read more here.
Keywords: crispr cas9; gene editing; trap gene; cas9 gene ... See more keywords
CRISPR/Cas9 Genome-Editing Technology and Potential Clinical Application in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112029
Abstract: Gastric cancer is the subject of clinical and basic studies due to its high incidence and mortality rates worldwide. Due to the diagnosis occurring in advanced stages and the classic treatment methodologies such as gastrectomy… read more here.
Keywords: crispr cas9; cas9 genome; editing technology; gastric cancer ... See more keywords
Application of Gene Editing Technology in Resistance Breeding of Livestock
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12071070
Abstract: As a new genetic engineering technology, gene editing can precisely modify the specific gene sequence of the organism’s genome. In the last 10 years, with the rapid development of gene editing technology, zinc-finger nucleases (ZFNs),… read more here.
Keywords: gene editing; gene; editing technology; resistance breeding ... See more keywords
A New Strategy for Efficient Screening and Identification of Monoclonal Antibodies against Oncogenic Avian Herpesvirus Utilizing CRISPR/Cas9-Based Gene-Editing Technology
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14092045
Abstract: Marek’s disease virus (MDV) is an important oncogenic α-herpesvirus that induces Marek’s disease (MD), characterized by severe immunosuppression and rapid-onset T-cell lymphomas in its natural chicken hosts. Historically, MD is regarded as an ideal biomedical… read more here.
Keywords: based gene; crispr cas9; gene editing; cas9 based ... See more keywords