High prevalence of unusual KRAS, NRAS, and BRAF mutations in POLE ‐ hypermutated colorectal cancers
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DOI: 10.1002/1878-0261.13257
Abstract: Exonucleasic domain POLE (edPOLE) mutations, which are responsible for a hypermutated tumor phenotype, occur in 1–2% of colorectal cancer (CRC) cases. These alterations represent an emerging biomarker for response to immune checkpoint blockade. This study… read more here.
Keywords: edpole mutations; edpole mutated; high prevalence; prevalence ... See more keywords