Abstract 7189: EED inhibitor APG-5918 renders vulnerability to immunotherapy by rewiring sphingolipid metabolism via nSMase2-ceramide pathway in pancreatic cancer
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DOI: 10.1158/1538-7445.am2025-7189
Abstract: Pancreatic cancer has a poor prognosis and is primary resistant to immune checkpoint inhibitors (ICIs) partially due to the inhibitory immune microenvironment. To improve the responsiveness of pancreatic cancer to ICIs, researchers have explored various… read more here.
Keywords: cancer; apg 5918; eed inhibitor; inhibitor apg ... See more keywords