In-Silico Screening-Based Discovery of New Natural eEF2K Inhibitors with Neuritogenic Activity.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00635
Abstract: Eukaryotic elongation factor 2 kinase (eEF2K), an atypical Ser/Thr-protein kinase that regulates neuronal protein synthesis homeostasis via an inhibitory phosphorylation of eEF2, has emerged as a promising therapeutic target for several diseases, including Alzheimer's disease… read more here.
Keywords: natural eef2k; eef2k inhibitors; eef2k; protein ... See more keywords
Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells
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DOI: 10.1111/jnc.16300
Abstract: Misfolding and accumulation of amyloid‐β (Aβ) in the brains of patients with Alzheimer's disease (AD) lead to neuronal loss through various mechanisms, including the downregulation of eukaryotic elongation factor 2 (EEF2) protein synthesis signaling. This… read more here.
Keywords: phosphorylation; folding reporter; eef2k; coumarin derivatives ... See more keywords
Abstract 6: Targeting eukaryotic elongation factor 2 kinase (eEF2K) to combat cancer stem cells and tumorigenesis in triple-negative breast cancer
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DOI: 10.1158/1538-7445.am2025-6
Abstract: Breast cancer remains the most commonly diagnosed cancer and the second leading cause of cancer-related deaths among women. Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers, is a highly aggressive and lethal… read more here.
Keywords: cancer; breast cancer; eef2k; tumor ... See more keywords
Increased eEF2K Promotes Glycolysis and Aggressive Behaviors of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
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DOI: 10.2147/jir.s337620
Abstract: Objective Aggressive phenotype and abnormal glycolytic metabolism of fibroblast-like synoviocytes (FLSs) are essential to joint inflammation and damage in rheumatoid arthritis (RA). Eukaryotic elongation factor-2 kinase (eEF2K) is a negative regulator of protein synthesis and… read more here.
Keywords: glycolysis aggressive; rheumatoid arthritis; like synoviocytes; arthritis ... See more keywords
Homozygous knockout of eEF2K alleviates cognitive deficits in APP/PS1 Alzheimer’s disease model mice independent of brain amyloid β pathology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.959326
Abstract: Maintenance of memory and synaptic plasticity depends on de novo protein synthesis, and accumulating evidence implicates a role of dysregulated mRNA translation in cognitive impairments associated with Alzheimer’s disease (AD). Accumulating evidence demonstrates hyper-phosphorylation of… read more here.
Keywords: disease; pathology; model; mice ... See more keywords
eEF2K Inhibitor Design: The Progression of Exemplary Structure-Based Drug Design
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DOI: 10.3390/molecules28031095
Abstract: The α-kinase, eEF2K, phosphorylates the threonine 56 residue of eEF2 to inhibit global peptide elongation (protein translation). As a master regulator of protein synthesis, in combination with its unique atypical kinase active site, investigations into… read more here.
Keywords: design; based drug; eef2k; drug ... See more keywords