Structure of the ACF7 EF-Hand-GAR Module and Delineation of Microtubule Binding Determinants.
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DOI: 10.1016/j.str.2017.05.006
Abstract: Spectraplakins are large molecules that cross-link F-actin and microtubules (MTs). Mutations in spectraplakins yield defective cell polarization, aberrant focal adhesion dynamics, and dystonia. We present the 2.8 Å crystal structure of the hACF7 EF1-EF2-GAR MT-binding module… read more here.
Keywords: gar domain; module; ef1 ef2; structure ... See more keywords