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Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2912
Abstract: The antiretroviral drug efavirenz remains widely used in children and mothers during breastfeeding in tuberculosis-endemic areas. Evaluating the safety of efavirenz during breastfeeding requires an understanding of its pharmacokinetics in breast milk, its exposure in…
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Keywords:
efavirenz;
mothers breastfeeding;
breastfeeding infants;
cyp2b6 ... See more keywords
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Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.12.038
Abstract: BACKGROUND & AIMS The most prescribed non-nucleoside reverse transcriptase inhibitor, efavirenz, has been associated with elevated risk of dyslipidemia and hepatic steatosis in HIV-infected patients but the underlying mechanisms remain elusive. Herein, we investigated the…
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Keywords:
hepatic steatosis;
efavirenz;
non nucleoside;
pxr ... See more keywords
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Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.07.013
Abstract: Patients living with HIV in malarial endemic regions may experience clinically significant drug interaction between antiretroviral and antimalarial drugs. Effects of nevirapine (NVP), efavirenz (EFV) and lopinavir/ritonavir (LPVr) on lumefantrine (LM) therapeutic concentrations and toxicity…
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Keywords:
living hiv;
efavirenz;
toxicity;
lopinavir ritonavir ... See more keywords
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1
Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.050
Abstract: The analysis of the thermal behavior of efavirenz showed a high glass-forming ability and good glass stability of this glass-forming liquid at room temperature. No polymorphic forms were formed either by cold crystallization or by…
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Keywords:
drs;
relaxation;
thermal behavior;
efavirenz ... See more keywords
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Published in 2021 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001433
Abstract: Introduction. Biofilm formation and hemolysis are closely related to the pathogenicity of Staphylococcus aureus.Hypothesis/Gap Statement. Strategies that reduce the mortality of S. aureus infections may involve novel antimicrobials and/or drugs that decrease S. aureus virulence,…
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Keywords:
virulence;
efavirenz;
biofilm formation;
hemolysis ... See more keywords
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1
Published in 2019 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190019868358
Abstract: Background: Efavirenz (Sustiva®) is used for the treatment of human immunodeficiency virus (HIV) type 1 infection. Hepatoxicity is a known potential adverse drug event with efavirenz; however, to our knowledge, vanishing bile duct syndrome (VBDS),…
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Keywords:
efavirenz;
case;
bile duct;
efavirenz induced ... See more keywords
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Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0202706
Abstract: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used in first-line combination antiretroviral therapy (cART). It is usually administered with nucleoside reverse transcriptase inhibitors (NRTI), many of which are substrates of OCT uptake solute carriers…
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Keywords:
efavirenz;
mate;
mate mate;
lamivudine ... See more keywords
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1
Published in 2022 at "Biomolecules"
DOI: 10.3390/biom13010088
Abstract: Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the spread of HIV. In 1998, the FDA authorized efavirenz for the…
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Keywords:
efavirenz;
hiv;
efavirenz history;
development future ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13246232
Abstract: Simple Summary Cancer stem cells (CSCs) are responsible for tumour initiation, chemo- and radiotherapy resistance and cancer recurrence. CSCs display plasticity that enables them to alter their phenotype and function making them challenging to eliminate.…
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Keywords:
cancer;
breast;
breast cancer;
efavirenz ... See more keywords
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Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7523
Abstract: The non-nucleoside reverse transcriptase inhibitor (NNRTI) Efavirenz is frequently used in human immunodeficiency virus treatment, but also efficient against cancer in mouse models. Its radiosensitizing effect makes it a promising drug for combination with radiotherapy.…
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Keywords:
efavirenz;
effect;
cancer cells;
cancer ... See more keywords