Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
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DOI: 10.1093/jac/dky378
Abstract: Objectives To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and… read more here.
Keywords: dose rifampicin; isoniazid; isoniazid acetyl; pharmacokinetics isoniazid ... See more keywords
Low-frequency pre-treatment HIV drug resistance: effects on 2-year outcome of first-line efavirenz-based antiretroviral therapy
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DOI: 10.1097/qad.0000000000003361
Abstract: Objective(s): Assess the impact of pre-treatment high-frequency and low-frequency drug-resistant HIV variants on long-term outcomes of first-line efavirenz-based antiretroviral therapy (ART). Design: Prospective observational study. Methods: Participants’ pre-treatment plasma RNA had two sections of HIV… read more here.
Keywords: frequency; efavirenz based; resistance; pre treatment ... See more keywords
Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial
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DOI: 10.1186/s12936-019-2818-7
Abstract: BackgroundHIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Artemether–lumefantrine (AL) is the most commonly used ACT for treatment of falciparum malaria in Africa but there is… read more here.
Keywords: trial; treatment; falciparum; therapy ... See more keywords