The Pharmacogenetics of Efavirenz Metabolism in Children: The Potential Genetic and Medical Contributions to Child Development in the Context of Long-Term ARV Treatment.
Sign Up to like & getrecommendations! Published in 2020 at "New directions for child and adolescent development"
DOI: 10.1002/cad.20353
Abstract: Efavirenz (EFV) is a well-known, effective anti-retroviral drug long used in first-line treatment for children and adults with HIV and HIV/AIDS. Due to its narrow window of effective concentrations, between 1 and 4 μg/mL, and… read more here.
Keywords: treatment; pharmacogenetics efavirenz; metabolism children; development ... See more keywords
Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.086348
Abstract: Efavirenz (more specifically the S-enantiomer) is a cornerstone antiretroviral therapy for treatment of HIV infection. The major primary metabolite is S-8-hydroxyefavirenz, which does not have antiretroviral activity but is neurotoxic. Cytochrome P450 2B6 (CYP2B6) is… read more here.
Keywords: cyp2b6; efavirenz hydroxylation; cyp2b6 variants; efavirenz metabolism ... See more keywords