CRISPR‐Mediated Enzyme Fragment Complementation Assay for Quantification of the Stability of Splice Isoforms
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DOI: 10.1002/cbic.202200012
Abstract: Small‐molecule splicing modulators exemplified by an FDA‐approved drug, risdiplam, are a new pharmacological modality for regulating the expression and stability of splice isoforms. We report a CRISPR‐mediated enzyme fragment complementation (EFC) assay to quantify the… read more here.
Keywords: complementation; efc assay; stability splice; crispr mediated ... See more keywords