Determination of chlorogenic acid, polyphenols and antioxidants in green coffee by thin-layer chromatography, effect-directed analysis and dot blot - comparison to HPLC and spectrophotometry methods.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201801174
Abstract: The great prevalence of thin-layer chromatography over high-performance liquid chromatography is connected with the possibility of analyzing many samples in parallel. Therefore, the method is often used in screening and/or effect directed analysis to compare… read more here.
Keywords: chromatography; layer chromatography; effect directed; thin layer ... See more keywords
Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05424-4
Abstract: The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and environmental health. With advances in analytical techniques, in particular, high-resolution mass… read more here.
Keywords: high throughput; effect directed; directed analysis; eda ... See more keywords
Integrating Effect-Directed Analysis and Chemically Indicative Mass Spectral Fragmentation to Screen for Toxic Organophosphorus Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04842
Abstract: Analytical chemists are often challenged to screen for bioactive compounds in complex matrices, sometimes without a priori knowledge of the exact compound of interest. Therefore, "flagging" techniques, highlighting common characteristics of bioactive compounds, are highly… read more here.
Keywords: integrating effect; directed analysis; screen; organophosphorus ... See more keywords
High-Performance Data Processing Workflow Incorporating Effect-Directed Analysis for Feature Prioritization in Suspect and Nontarget Screening
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.1c04168
Abstract: Effect-directed analysis (EDA) aims at the detection of bioactive chemicals of emerging concern (CECs) by combining toxicity testing and high-resolution mass spectrometry (HRMS). However, consolidation of toxicological and chemical analysis techniques to identify bioactive CECs… read more here.
Keywords: high performance; analysis; workflow incorporating; directed analysis ... See more keywords
Effect-Directed Synthesis of PhoP/PhoQ Inhibitors to Regulate Salmonella Virulence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01087
Abstract: Salmonella spp. are among the leading bacterial causes of foodborne infections. The PhoP/PhoQ two-component regulatory system serves as a master virulence regulator in Salmonella. Although PhoP/PhoQ represents an ideal target for disarming Salmonella virulence, it… read more here.
Keywords: phop phoq; salmonella virulence; directed synthesis; effect directed ... See more keywords
Identification of the estrogen-active compounds via integrating effect-directed analysis and non-target screening in soils of the northeastern China
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Sciences Europe"
DOI: 10.1186/s12302-024-00885-x
Abstract: Background The gaps between estrogenic effect and its effect-active compounds exist frequently due to a large number of compounds that have been reported to induce this effect and the occurrence of pollutants in environments as… read more here.
Keywords: effect directed; effect; estrogen active; directed analysis ... See more keywords
Identification of antimicrobial and glucocorticoid compounds in wastewater effluents with effect-directed analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental research"
DOI: 10.2139/ssrn.4283611
Abstract: Pharmaceuticals, such as glucocorticoids and antibiotics, are inadequately removed from wastewater and may cause unwanted toxic effects in the receiving environment. This study aimed to identify contaminants of emerging concern in wastewater effluent with antimicrobial… read more here.
Keywords: glucocorticoid; analysis; activity; effect directed ... See more keywords
Effect-Directed, Chemical and Taxonomic Profiling of Peppermint Proprietary Varieties and Corresponding Leaf Extracts
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020476
Abstract: During the development of novel, standardized peppermint extracts targeting functional applications, it is critical to adequately characterize raw material plant sources to assure quality and consistency of the end-product. This study aimed to characterize existing… read more here.
Keywords: peppermint; directed chemical; chemical taxonomic; profiling ... See more keywords
Schisandra rubriflora Fruit and Leaves as Promising New Materials of High Biological Potential: Lignan Profiling and Effect-Directed Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072116
Abstract: The effect-directed detection (EDD) of Schisandra rubriflora fruit and leaves extracts was performed to assess their pharmacological properties. The EDD comprised TLC—direct bioautography against Bacillus subtilis, a DPPH assay, as well as α-glucosidase, lipase, tyrosinase,… read more here.
Keywords: rubriflora fruit; schisandra rubriflora; fruit leaves; fruit ... See more keywords
Effect-Directed Profiling of Monofloral Honeys from Ethiopia by High-Performance Thin-Layer Chromatography and High-Resolution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113541
Abstract: Ethiopian honey is used not only as food but also for treatment in traditional medicine. For its valorization, bioactive compounds were analyzed in nine types of monofloral Ethiopian honey. Therefore, a non-target effect-directed profiling was… read more here.
Keywords: effect; directed profiling; activity; high performance ... See more keywords
Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27186062
Abstract: Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17… read more here.
Keywords: varieties breeding; profiling strawberry; directed profiling; effect directed ... See more keywords