Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation
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DOI: 10.1097/tp.0000000000001941
Abstract: Background Ischemia-reperfusion injury after liver transplantation (LT) impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether… read more here.
Keywords: fk506; hepatoprotective effect; effect fk506; effect ... See more keywords
Novel immunosuppressive effect of FK506 by upregulation of PD‐L1 via FKBP51 in heart transplantation
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DOI: 10.1111/sji.13203
Abstract: The calcineurin inhibitor–FK506–is a first‐line immunosuppressant that regulates T cell secretion of IL‐2 and other cytokines. However, the mechanism of its protective effect on target cells and its role on tumour recurrence and interaction with… read more here.
Keywords: cell; effect; immunosuppressive effect; effect fk506 ... See more keywords