The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09681-2
Abstract: Although guanosine is an endogenous nucleoside that displays antidepressant-like properties in several animal models, the mechanism underlying its antidepressant-like effects is not well characterized. The present study aimed at investigating the involvement of ERK/GSK-3β and… read more here.
Keywords: like effect; gsk; effect guanosine; antidepressant like ... See more keywords
Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways
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DOI: 10.1080/15257770.2016.1268693
Abstract: ABSTRACT This study aims to investigate the mechanisms associated with the antiproliferation effect of guanosine on human colon carcinoma HCT 116 cells. In this study, guanosine induced more drastic cell cycle arrest effect than cell… read more here.
Keywords: 116 cells; hct 116; guanosine; effect guanosine ... See more keywords