Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.018
Abstract: Continuous development of new antibacterial agents is necessary to counter the problem of antimicrobial resistance. Polymyxins are considered as drugs of last resort to combat multidrug-resistant Gram-negative pathogens. Structural optimization of polymyxins requires an in-depth… read more here.
Keywords: component; dilipid polymyxins; polymyxin; effect hydrophobicity ... See more keywords
Aggregation and charge reversal of humic substances in the presence of hydrophobic monovalent counter-ions: Effect of hydrophobicity of humic substances
Sign Up to like & getrecommendations! Published in 2018 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2017.12.065
Abstract: Abstract To investigate the effect of hydrophobicity of humic substances (HSs) on their charging and aggregation, we studied the electrophoretic mobility and aggregation-dispersion of HSs in the presence of hydrophobic monovalent cations, namely, tetraphenylphosponium TPP+.… read more here.
Keywords: hydrophobicity humic; presence hydrophobic; presence; hydrophobic monovalent ... See more keywords
Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00767
Abstract: Passive diffusion across biomembranes is an important mechanism of permeation for multiple drugs, including antibiotics. However, this process is frequently neglected while studying drug uptake and, in our view, warrants further investigation. Here, we apply… read more here.
Keywords: permeation; model; membrane; effect hydrophobicity ... See more keywords