Protective effect of metformin against rotenone-induced parkinsonism in mice
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2020.1741053
Abstract: Abstract Rotenone is a mitochondrial complex I inhibitor, which can cause the death of dopaminergic (DA) neurons and Parkinson’s disease (PD). Currently, whether metformin has a protective effect on neurotoxicity induced by rotenone is unclear.… read more here.
Keywords: protective effect; rotenone induced; effect metformin; rotenone ... See more keywords
14-3-3zeta is involved in the anticancer effect of metformin in colorectal carcinoma
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DOI: 10.1093/carcin/bgy008
Abstract: Metformin is a promising drug for cancer prevention and treatment, especially in the diabetic population. We aimed to test whether 14-3-3zeta affects the anticancer effect of metformin on colorectal carcinoma (CRC). In this study, we… read more here.
Keywords: anticancer effect; metformin; colorectal carcinoma; effect metformin ... See more keywords
Effect of Metformin or Chinese Herbal Formula in Patients with Type 2 Diabetes Mellitus and Hyperlipidemia: A Reassessment
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.01173-18
Abstract: We have read the article “Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open … read more here.
Keywords: herbal formula; effect metformin; type diabetes; metformin chinese ... See more keywords
The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Endocrinology"
DOI: 10.1155/2020/5150684
Abstract: Objective Metformin is an important component of PCOS treatment. At present, the effect of metformin in overweight women with PCOS has not been evaluated. Therefore, we conducted a systematic review to assess the effects of… read more here.
Keywords: hormone; metformin overweight; overweight women; effect metformin ... See more keywords
Abstract 15729: Effect of Metformin on Outcomes of Catheter Ablation for Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15729
Abstract: Background: Diabetes mellitus (DM) and glycemic control are risk factors for atrial fibrillation (AF). Metformin may have antifibrillatory properties by altering atrial metabolism. It is unknown wh... read more here.
Keywords: effect metformin; abstract 15729; fibrillation; atrial fibrillation ... See more keywords
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280792
Abstract: The anti-fibrotic effect of metformin has been widely demonstrated. Fibrosis in the kidney after injury is associated with reduced expression of genes involved in both fatty acid and glycolytic energy metabolism. We have previously reported… read more here.
Keywords: pfkfb2; effect metformin; fibrotic effect; metformin ... See more keywords
Effect of metformin on clinical and biochemical hyperandrogenism in adolescent girls with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2018-0430
Abstract: Abstract Background Hyperandrogenism with or without polycystic ovarian syndrome is seen in adolescents with type 1 diabetes (T1D), especially those with suboptimal control. Objective To assess the effect of metformin on hyperandrogenism and ovarian function… read more here.
Keywords: clinical biochemical; hyperandrogenism; effect metformin; adolescent girls ... See more keywords
Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer
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DOI: 10.3390/cancers12092554
Abstract: Simple Summary Tumor suppressing effect of metformin has been reported, and one of mechanism of this effect is suppression of cancer stem cells (CSCs). However, detailed mechanism of metformin-induced CSC-inhibitory effect has not been known.… read more here.
Keywords: mevalonate; colorectal cancer; metformin; effect metformin ... See more keywords
Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18061282
Abstract: Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms… read more here.
Keywords: postprandial hypertriglyceridemia; administration; metformin; effect metformin ... See more keywords
The Hormetic Effect of Metformin: “Less Is More”?
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DOI: 10.3390/ijms22126297
Abstract: Metformin (MTF) is the first-line therapy for type 2 diabetes (T2DM). The euglycemic effect of MTF is due to the inhibition of hepatic glucose production. Literature reports that the principal molecular mechanism of MTF is… read more here.
Keywords: metformin less; mtf; hormetic effect; effect metformin ... See more keywords
In Vitro and In Ovo Evaluation of the Potential Hepatoprotective Effect of Metformin
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DOI: 10.3390/medicina58060705
Abstract: Background and Objectives: Metformin is currently the leading drug of choice for treating type 2 diabetes mellitus, being one of the most widely used drugs worldwide. The beneficial effects of Metformin, however, extend far beyond… read more here.
Keywords: effect; effect metformin; vitro ovo; hepatoprotective effect ... See more keywords