Effect of the nonleaving groups on the cellular uptake and cytotoxicity of platinum-acridine anticancer agents
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DOI: 10.1016/j.ica.2019.04.030
Abstract: Abstract Three new derivatives of a platinum–acridine hybrid anticancer agent were synthesized using nitrile–amine coupling (amidination) chemistry. In the new structures, the nonleaving group propane-1,3-diamine (pn) of a previously optimized analogue (hybrid 1) was replaced… read more here.
Keywords: cytotoxicity; anticancer; effect nonleaving; cellular uptake ... See more keywords