Substituent Effect on the Nucleophilic Aromatic Substitution of Thiophenes With Pyrrolidine: Theoretical Mechanistic and Reactivity Study
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DOI: 10.1002/jcc.70169
Abstract: Aromatic nucleophilic substitution (SNAr) is a widely employed synthetic method for modifying thiophene derivatives. Herein, we computationally investigate the reaction mechanism of 2‐methoxy‐3‐X‐5‐nitrothiophenes with pyrrolidine (where X = NO2, CN, SO2CH3, COCH3, CO2CH3, CONH2 or H). This… read more here.
Keywords: substitution; chemistry; effect nucleophilic; substituent effect ... See more keywords