Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity.
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DOI: 10.1016/j.bcp.2020.113975
Abstract: BACKGROUND AND PURPOSE Rapamycin is a potent immunosuppressant and anti-proliferative agent used clinically to prevent organ transplant rejection and for coating coronary stents to counteract restenosis. Rapamycin complexes with the immunophilin FKBP12, which subsequently binds… read more here.
Keywords: platelet procoagulant; procoagulant responses; integrity; effect rapamycin ... See more keywords