The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus
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DOI: 10.1002/jcph.955
Abstract: Ertugliflozin is a highly selective and potent inhibitor of the sodium‐glucose cotransporter 2 in development for the treatment of type 2 diabetes mellitus. The glycemic efficacy of sodium‐glucose cotransporter 2 inhibitors such as ertugliflozin depends… read more here.
Keywords: effect renal; type diabetes; diabetes mellitus; impairment pharmacokinetics ... See more keywords
Prediction of the Effect of Renal Impairment on the Pharmacokinetics of New Drugs
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DOI: 10.1007/s40262-017-0574-9
Abstract: IntroductionRenal impairment may have a significant impact on the pharmacokinetics of drugs. Ad hoc studies in subjects with renal impairment are required by the regulatory authorities to propose dose adjustments in these subjects, to find… read more here.
Keywords: exposure; effect renal; impairment; renal impairment ... See more keywords
Clinical expression of microRNA‐144‐5p and its regulatory effect on renal function in uremia
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DOI: 10.1111/1744-9987.13922
Abstract: The study commits to probing the clinical expression of microRNA‐144‐5p (miR‐144‐5p) and its modulatory effect on the renal function of uremia. read more here.
Keywords: expression microrna; microrna 144; renal function; function uremia ... See more keywords
Effect of Renal Impairment on the Pharmacokinetics and Safety of Dorzagliatin, a Novel Dual-acting Glucokinase Activator.
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DOI: 10.1111/cts.13174
Abstract: Dorzagliatin is a novel allosteric glucokinase activator targeting both pancreatic and hepatic glucokinase currently under clinical investigation for treatment of type 2 diabetes (T2D). This study aimed to investigate the effect of renal impairment (RI)… read more here.
Keywords: dorzagliatin novel; glucokinase; effect renal; glucokinase activator ... See more keywords
Lack of a “Weekend Effect” for Renal Transplant Recipients
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DOI: 10.1177/0003319716660245
Abstract: The “weekend (WE) effect” defines the association between WE hospital admissions and higher rate of mortality. The aim of this study was to evaluate the relationship between WE effect and renal transplant recipients (RTRs) using… read more here.
Keywords: effect renal; transplant recipients; weekend effect; renal transplant ... See more keywords
Effect of renal impairment (RI) on intravenous bisphosphonates (IVBP) and multiple myeloma (MM) treatment.
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DOI: 10.1200/jco.2018.36.15_suppl.e20007
Abstract: e20007Background: RI is prevalent in MM patients and associated with poor survival and increased costs. IVBPs are recommended to prevent skeletal-related event (SREs), a common and devastating comp... read more here.
Keywords: bisphosphonates ivbp; ivbp multiple; effect renal; intravenous bisphosphonates ... See more keywords
Favorable effect of renal denervation on elevated renal vascular resistance in patients with resistant hypertension and type 2 diabetes mellitus
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DOI: 10.3389/fcvm.2022.1010546
Abstract: Objective To assess the effect of renal denervation (RDN) on renal vascular resistance and renal function in patients with drug-resistant hypertension (HTN) and type 2 diabetes mellitus (T2DM). Materials and methods Fifty-nine patients (mean age… read more here.
Keywords: renal denervation; vascular resistance; effect renal; renal vascular ... See more keywords