Effect of sildenafil on neuroinflammation and synaptic plasticity pathways in experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106581
Abstract: Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with… read more here.
Keywords: neuroinflammation synaptic; synaptic plasticity; effect sildenafil; plasticity ... See more keywords
The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation
Sign Up to like & getrecommendations! Published in 2019 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.13431
Abstract: We evaluated whether the administration of sildenafil in children undergoing the TCPC operation shortened the interval from the operation to the removal of the pleural and peritoneal drains. read more here.
Keywords: tcpc operation; sildenafil pleural; pleural peritoneal; operation ... See more keywords
Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20122992
Abstract: Sirt1 (Sirtuin 1), AMPK (AMP-activated protein kinase), and eNOS (endothelial nitric oxide synthase) modulate hepatic energy metabolism and inflammation and play a major role in the development of NASH. Cyclic nucleotide phosphodiesterases (PDEs) play an… read more here.
Keywords: sildenafil energy; energy; higher sildenafil; biphasic effect ... See more keywords