Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112755
Abstract: Liver cancer is one of the most common and high recurrence malignancies. Besides radiotherapy and surgery, chemotherapy also plays an essential role in the treatment of liver cancer. Sorafenib and sorafenib-based combination therapies have been… read more here.
Keywords: liver cancer; effect sorafenib; sorafenib; cancer cells ... See more keywords
Abstract 1025: Mechanism of antitumor effect of Sorafenib in anaplastic thyroid cancer cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1158/1538-7445.am2019-1025
Abstract: Introduction: Anaplastic thyroid cancer (ATC) is a rare refractory disease, found in 1-3% of thyroid cancer. Because of its highly malignant potential, patients often become lethal within 6 months, nevertheless for intensive multimodal therapies. Recent… read more here.
Keywords: effect sorafenib; cancer; cell; thyroid cancer ... See more keywords
Chenodeoxycholic Acid Enhances the Effect of Sorafenib in Inhibiting HepG2 Cell Growth Through EGFR/Stat3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.836333
Abstract: Background Hepatocellular carcinoma (HCC) is a highly invasive disease with a high mortality rate. Our previous study found that Chenodeoxycholic acid (CDCA) as an endogenous metabolite can enhance the anti-tumor effect. Sorafenib has limited overall… read more here.
Keywords: effect; effect sorafenib; cell growth; hepg2 cell ... See more keywords
Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells
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DOI: 10.7150/ijms.19033
Abstract: Background: Currently, sorafenib is the only systemic chemotherapy drug for advanced stage Hepatocellular carcinoma (HCC). However, emerging data from some clinical HCC patients indicate that sorafenib alone has only moderate antitumor efficacy, and could not… read more here.
Keywords: hepatocellular carcinoma; combination; hcc; effect sorafenib ... See more keywords