A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma
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DOI: 10.1111/nan.12837
Abstract: Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the incidence of tumours, including medulloblastoma (MB). On the other hand, MRE11, RAD50 and NBS1 protein components of the MRN complex are often… read more here.
Keywords: dosage dependent; unveils nbs1; dependent effect; effect unveils ... See more keywords