Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
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DOI: 10.1002/epi4.12604
Abstract: Objective CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient… read more here.
Keywords: antiseizure; clemizole trazodone; zebrafish model; effective antiseizure ... See more keywords