1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2142787
Abstract: Abstract A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxybenzaldehydes in their reaction with sulfamoyl chloride. 5-, 7-, and 8-aryl substituted 1,2,3-benzoxathiazine-2,2-dioxides were prepared from… read more here.
Keywords: human carbonic; inhibitors human; effective inhibitors; benzoxathiazine dioxides ... See more keywords
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
Sign Up to like & getrecommendations! Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9110833
Abstract: β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge.… read more here.
Keywords: effective inhibitors; designing effective; exploit lactamases; lactamases intrinsic ... See more keywords