LAUSR

Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

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0 Published in 2018 at "Thorax"

DOI: 10.1136/thoraxjnl-2017-210670

Abstract: Introduction Loss of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to upregulation of the epithelial sodium channel (ENaC). Thickened mucus and… read more here.

Keywords: cystic fibrosis; mouse lung; enac; effective silencing ... See more keywords